Scientific Approach

Our unique pathogen-targeted approach uses genetics, molecular dynamics simulations and medicinal chemistry to design novel antibacterials

At Entasis, our drug discovery platform combines the use of genetics tools, molecular dynamics simulations and modeling to enable exploration of novel therapies in a highly directed, focused manner to design compounds with improved efficacy for these very challenging pathogens.

Novel strategies for developing antibiotics are needed, as infections caused by multidrug-resistant organisms are a leading threat to public health. Along with industry partners, academia and regulators, Entasis Therapeutics is committed to the concept of streamlined development programs focused on pathogen-directed antibacterials that may target only a single species of highly resistant bacterial pathogens in areas of high unmet medical need. The emergence of new, non–culture-based, rapid diagnostic testing makes the strategic shift towards pathogen-directed therapies much more feasible. As a leader in this area, we have focused on one of the most concerning antibiotic-resistant pathogens: carbapenem-resistant Acinetobacter baumannii.

Our strong knowledge of chemistry and structural biology, together with a deep understanding of the genetics and genomics of Gram-negative bacteria, have helped us advance early leads and identify novel, differentiated clinical candidates.

Our ability to leverage lab-based automation, in vitro hollow-fiber technologies and mass spectrometry to define exposure-efficacy relationships rapidly led to an early understanding of clinical dose setting – a key aspect of a streamlined development strategy.

“One of the things I love about working at Entasis is that we have the culture and feel of a small biotech, combined with great science, depth of expertise and pipeline of a leading global pharmaceutical company.”

— Jing Zhang, Senior Scientist