Our Science

Publications 2014

Lahiri SD, Johnstone M, Ross PL, McLaughlin R, Olivier NB, Alm RA
Avibactam and class C ß-lactamases: mechanism of inhibition, conservation of binding pocket and implications for resistance
Antimicrobial Agents and Chemotherapy (2014)

Alm R, Lahiri S, Kutschke A, Otterson L, McLaughlin R, Whiteaker J, Lewis L, Su X, Huband M, Gardner H, Mueller J
Characterization of the novel DNA gyrase inhibitor AZD0914: Low resistance potential and lack of cross-resistance in Neisseria gonorrhoeae
Antimicrobial Agents and Chemotherapy (2014)

Shapiro AB, Gu R, Gao N
Dimerization of isolated Pseudomonas aeruginosa lipopolysaccharide transporter component
ScienceDirect (2014)

Xiong H, Chen B, Durand-Réville T, Joubran C, Alelyunas Y, Wu D,Huynh H
Enantioselective Synthesis and Profiling of Two Novel Diazabicyclooctanone ß-Lactamase Inhibitors
ACS Publications (2014)

Campbell AJ, Lamb ML, Joseph-McCarthy D
Ensemble-Based Docking Using Biased Molecular Dynamics
Journal of Chemical Information and Modeling (2014)

Shapiro AB, Gao N, Gu R, Thresher J
Fluorescence anisotropy-based measurement of acylation rate constants for inhibitors of Penicillin-Binding Protein 2 (PBP2) transpeptidase of Pseudomonas aeruginosa
Analytical Biochemistry (2014)

Jacobsson S, Golparian D, Alm RA, Huband M, Mueller J, Skov Jensen J, Ohnishi M, Unemoa M
High in vitro activity of the novel spiropyrimidinetrione AZD0914, a DNA gyrase inhibitor, against multidrug resistant Neisseria gonorrhoeae isolates suggests a new effective option for oral treatment of gonorrhea
Antimicrobial Agents and Chemotherapy (2014)

Kohlhoff S, Huband M, Hammerschlag M
In vitro activity of AZD0914, a novel DNA gyrase inhibitor, against Chlamydia trachomatis and Chlamydia pneumoniae
Antimicrobial Agents and Chemotherapy (2014)

Huband M, Bradford P, Otterson L, Basarab G, Kutschke A, Giacobbe R, Patey S, Alm R, Johnstone M, Potter M, Miller P, Mueller J
In Vitro Antibacterial Activity of AZD0914: A New Spiropyrimidinetrione DNA Gyrase/Topoisomerase Inhibitor with Potent Activity against Gram-Positive, Fastidious Gram-Negative, and Atypical Bacteria
Antimicrobial Agents and Chemotherapy (2014)

Olivier NB, Altman RB, Noeske J, Basarab G, Code E, Ferguson AD, Gao N, Huang J, Juette M, Livchak S, Miller MD, Prince DB, Cate JHD, Buurman ET, Blanchard
Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome
PNAS (2014)

Brown DG, May-Dracka TL, Gagnon MM, Tommasi R
Trends and Exceptions of Physical Properties on Antibacterial Activity for Gram-Positive and Gram-Negative Pathogens
Journal of Medicinal Chemistry (2014)

Basarab GS, Brassil P, Doig P, Galullo V, Haimes HB, Kern G, Kutschke A, McNulty J, Schuck VJ, Stone G, Gowravaram M
Novel DNA Gyrase Inhibiting Spiropyrimidinetriones with a Benzisoxazole Scaffold: SAR and in Vivo Characterization
Journal of Medicinal Chemistry (2014)

Basarab G, Galullo V, DeGrace N, Hauck S, Joubran C, Wesolowski S
Synthesis of a Tetrahydronaphthyridine Spiropyrimidinetrione DNA Gyrase Inhibiting Antibacterial Agent – Differential Substitution at all Five Carbon Atoms of Pyridine
Organic Letters (2014)

Shapiro AB, Austin CA
A high-throughput fluorescence anisotropy-based assay for human topoisomerase IIb-catalyzed ATP-dependent supercoiled DNA relaxation
Analytical Biochemistry (2014)