About Entasis

Paul G Ambrose, Pharm. D., FIDSA
Paul G. Ambrose, Pharm.D., F.I.D.S.A., is President of the Institute for Clinical Pharmacodynamics (ICPD), Latham, New York, and an Honorary Research Fellow in Infectious Diseases at the University of Oxford, Oxford, UK and Adjunct Associate Research Professor at the University at Buffalo, Buffalo, New York. Dr. Ambrose’s areas of scientific inquiry primarily involve anti-infective translational science, with the goal of improving patient care through the application of pharmacokinetic-pharmacodynamic (PK-PD) principles. Dr. Ambrose received his Pharm.D. from the University of the Pacific and completed a Post-Doctoral Fellowship in infectious diseases at Hartford Hospital.

Karen Bush, PhD
Karen Bush, Ph.D., is a Fellow of the American Academy of Microbiology and a Professor of Practice in the biotechnology program in the Department of Molecular and Cellular Biology at Indiana University, where she is also an Adjunct Professor of Biology. She currently leads a small research group that evaluates new antibacterial agents and novel resistance mechanisms in carbapenem-resistant Enterobacteriaceae (CRE). Dr. Bush was involved with pharmaceutical research from 1973 to 2009, primarily working in the area of antibiotic drug discovery and development at Squibb (Bristol-Myers Squibb), Lederle (Wyeth), Astra and Johnson & Johnson Pharmaceutical Research & Development. She is especially known for her work on beta-lactamases. Dr. Bush was a member of research teams that served to discover and/or develop aztreonam, piperacillin-tazobactam, levofloxacin, doripenem and ceftobiprole. Dr. Bush received a Ph.D. in biochemistry from Indiana University.

Mark Noe, PhD
Mark Noe, Ph.D., is Vice President of the Groton Center of Chemistry Innovation, an interdisciplinary department comprised of structural biology, analytical chemistry, synthesis technology, experimental design and computational analysis supporting Worldwide Medicinal Chemistry. In addition to his scientific leadership, Dr. Noe leads a number of supporting teams within Pfizer Research and Development, including Academic and Industry Relations for the chemistry discipline. He serves on multiple external scientific advisory panels for both academia and the biotechnology industry. Dr. Noe received his Ph.D. in organic chemistry from Harvard University.